Translational control by viral ptoteinases

被引：101

作者：

Lloyd, Richard E. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

VIRUS RESEARCH | 2006年 / 119卷 / 01期

关键词：

proteinase; translation inhibition; eIF4G; PABP;

D O I：

10.1016/j.virusres.2005.10.016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Most RNA viruses have evolved strategies to regulate cellular translation in order to promote preferential expression of the viral genome. Positive strand RNA viruses express large portions, or all of their proteome via translation of large polyproteins that are processed by embedded viral proteinases or host proteinases. Several of these viral proteinases are known to interact with host proteins, particularly with the host translation machinery, and thus, encompass the dual functions of processing of viral polyproteins and exerting translation control. Picornaviruses are perhaps the best characterized in regards to interaction of their proteinases with the host translation machinery and will be emphasized here. However, new findings have shown that similar paradigms exist in other viral systems which will be discussed. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：76 / 88

页数：13

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