The microanatomy of B cell activation

被引：46

作者：

Phan, Tri Giang ^{[1
]}

Gray, Elizabeth E. ^{[2
,3
]}

Cyster, Jason G. ^{[2
,3
]}

机构：

[1] Garvan Inst Med Res, Sydney, NSW 2010, Australia

[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 03期

基金：

英国医学研究理事会;

关键词：

MARGINAL ZONE MACROPHAGES; MURINE MANNOSE RECEPTOR; DENDRITIC CELLS; LYMPH-NODES; IMMUNE-COMPLEXES; SUBCAPSULAR SINUS; T-CELLS; IN-VIVO; MEDIATED TRANSPORT; RETICULAR CELLS;

D O I：

10.1016/j.coi.2009.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The logistic problem of B cell antigen encounter in the lymph node has recently been studied by dynamic imaging using two-photon microscopy. These studies combined with the early studies of antigen transport have yielded a more complete picture of the orchestration of B cell activation in vivo. Here we summarize the recent advances and focus on the specialized macrophages that are critical to this process and the role of B cells themselves as antigen transporting cells.

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收藏

页码：258 / 265

页数：8

相关论文

共 72 条

[1] Imaging of germinal center selection events during affinity maturation [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Tang, H. Lucy ;

Cyster, Jason G. .

SCIENCE, 2007, 315 (5811) :528-531

[2]

Anderson A O, 1993, Semin Immunol, V5, P271, DOI 10.1006/smim.1993.1031

[3]

ANDERSON AO, 1975, AM J PATHOL, V80, P387

[4] Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes [J].

Bajenoff, Marc ;

Egen, Jackson G. ;

Koo, Lily Y. ;

Laugier, Jean Pierre ;

Brau, Frederic ;

Glaichenhaus, Nicolas ;

Germain, Ronald N. .

IMMUNITY, 2006, 25 (06) :989-1001

[5] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[6] LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan [J].

Banerji, S ;

Ni, J ;

Wang, SX ;

Clasper, S ;

Su, J ;

Tammi, R ;

Jones, M ;

Jackson, DG .

JOURNAL OF CELL BIOLOGY, 1999, 144 (04) :789-801

[7] The role of integrins and coreceptors in refining thresholds for B-cell responses [J].

Batista, Facundo D. ;

Arana, Eloisa ;

Barral, Patricia ;

Carrasco, Yolanda R. ;

Depoil, David ;

Eckl-Dorna, Julia ;

Fleire, Sebastian ;

Howe, Kathy ;

Vehlow, Anne ;

Weber, Michele ;

Treanor, Bebhinn .

IMMUNOLOGICAL REVIEWS, 2007, 218 :197-213

[8] Cell surface recycling of internalized antigen permits dendritic cell priming of B cells [J].

Bergtold, A ;

Desai, DD ;

Gavhane, A ;

Clyne, R .

IMMUNITY, 2005, 23 (05) :503-514

[9] LYMPHOCYTE-MEDIATED TRANSPORT OF AGGREGATED HUMAN GAMMA-GLOBULIN INTO GERMINAL CENTRE AREAS OF NORMAL MOUSE SPLEEN [J].

BROWN, JC ;

JESUS, DGD ;

HOLBOROW, EJ ;

HARRIS, G .

NATURE, 1970, 228 (5269) :367-&

[10] B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node [J].

Carrasco, Yolanda R. ;

Batista, Facundo D. .

IMMUNITY, 2007, 27 (01) :160-171

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