The microanatomy of B cell activation

被引：46

作者：

Phan, Tri Giang ^{[1
]}

Gray, Elizabeth E. ^{[2
,3
]}

Cyster, Jason G. ^{[2
,3
]}

机构：

[1] Garvan Inst Med Res, Sydney, NSW 2010, Australia

[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 03期

基金：

英国医学研究理事会;

关键词：

MARGINAL ZONE MACROPHAGES; MURINE MANNOSE RECEPTOR; DENDRITIC CELLS; LYMPH-NODES; IMMUNE-COMPLEXES; SUBCAPSULAR SINUS; T-CELLS; IN-VIVO; MEDIATED TRANSPORT; RETICULAR CELLS;

D O I：

10.1016/j.coi.2009.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The logistic problem of B cell antigen encounter in the lymph node has recently been studied by dynamic imaging using two-photon microscopy. These studies combined with the early studies of antigen transport have yielded a more complete picture of the orchestration of B cell activation in vivo. Here we summarize the recent advances and focus on the specialized macrophages that are critical to this process and the role of B cells themselves as antigen transporting cells.

引用

页码：258 / 265

页数：8