Signalling through the insulin receptor

被引：88

作者：

Whitehead, JP ^{[1
]}

Clark, SF

Urso, B

James, DE

机构：

[1] Univ Queensland, Ctr Mol & Cellular Biol, Brisbane, Qld 4072, Australia

[2] Univ Copenhagen 13, Copenhagen Muscle Res Ctr, Inst Exercise & Sport Sci, August Krogh Inst, DK-2100 Copenhagen O, Denmark

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0955-0674(99)00079-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor substrate isoforms appear to be associated with an insoluble matrix that resembles the cytoskeleton. When inappropriately dissociated from this matrix the signalling network collapses concomitant with loss of insulin sensitivity.

引用

页码：222 / 228

页数：7

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