The computational integrated myocyte - A view into the virtual heart

被引：14

作者：

Bassingthwaighte, JB ^{[1
]}

Vinnakota, KC ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

CARDIAC ENGINEERING: FROM GENES AND CELLS TO STRUCTURE AND FUNCTION | 2004年 / 1015卷

关键词：

integrative systems; modeling; cardiomyocyte;

D O I：

10.1196/annals.1302.034

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The presentation outlines an integrative approach for developing a computational model of cardiomyocytes. A modular approach is proposed, and strategies of linking the modules (intermediary metabolism, electrophysiology, and mechanics) of the model are presented. A strong recommendation is given toward an integrated system approach backed by experimental validation.

引用

页码：391 / 404

页数：14

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