Stimulatory effect of curcumin on osteoblast apoptosis

被引：75

作者：

Ozaki, K ^{[1
]}

Kawata, Y ^{[1
]}

Amano, S ^{[1
]}

Hanazawa, S ^{[1
]}

机构：

[1] Meikai Univ, Sch Dent, Dept Oral Microbiol, Sakado, Saitama 3500283, Japan

来源：

BIOCHEMICAL PHARMACOLOGY | 2000年 / 59卷 / 12期

关键词：

curcumin; osteoclasts; apoptosis; transcriptional factor; bone resorption;

D O I：

10.1016/S0006-2952(00)00277-X

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Curcumin is a potent inhibitor of the transcriptional factors activator protein-1 and nuclear factor-kappa B. Since transcriptional factors may play a functional role in the survival of osteoclasts, it was of interest to us to examine the effect of curcumin on osteoclast apoptosis. We observed that curcumin is a potent stimulator of this process in rabbit osteoclasts, as evidenced by morphological changes in nuclei and DNA fragmentation as criteria of apoptosis. The curcumin stimulation of the osteoclast apoptosis was dose-and treatment time-dependent. In addition, curcumin dramatically inhibited osteoclastic bone resorption, supporting our data that: curcumin is a potent stimulator of osteoclast apoptosis. (C) 2000 Elsevier Science Inc.

引用

页码：1577 / 1581

页数：5

共 28 条

[1]

AMANO S, 1992, J BONE MINER RES, V7, P321

[2]

PHARMACOLOGY OF CURCUMA-LONGA [J].

AMMON, HPT ;

WAHL, MA .

PLANTA MEDICA, 1991, 57 (01) :1-7

[3]

CHEMOPREVENTIVE EFFECT OF TURMERIC AGAINST STOMACH AND SKIN TUMORS INDUCED BY CHEMICAL CARCINOGENS IN SWISS MICE [J].

AZUINE, MA ;

BHIDE, SV .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1992, 17 (01) :77-83

[4]

An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[5]

PYRROLIDINE DITHIOCARBAMATE, A POTENT INHIBITOR OF NUCLEAR FACTOR KAPPA-B (NF-KAPPA-B) ACTIVATION, PREVENTS APOPTOSIS IN HUMAN PROMYELOCYTIC LEUKEMIA HL-60 CELLS AND THYMOCYTES [J].

BESSHO, R ;

MATSUBARA, K ;

KUBOTA, M ;

KUWAKADO, K ;

HIROTA, H ;

WAKAZONO, Y ;

LIN, YW ;

OKUDA, A ;

KAWAI, M ;

NISHIKOMORI, R ;

HEIKE, T .

BIOCHEMICAL PHARMACOLOGY, 1994, 48 (10) :1883-1889

[6]

REQUIREMENT OF PP60C-SRC EXPRESSION FOR OSTEOCLASTS TO FORM RUFFLED BORDERS AND RESORB BONE IN MICE [J].

BOYCE, BF ;

YONEDA, T ;

LOWE, C ;

SORIANO, P ;

MUNDY, GR .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (04) :1622-1627

[7]

COLOTTA F, 1992, J BIOL CHEM, V267, P18278

[8]

MACROPHAGE-COLONY-STIMULATING FACTOR STIMULATES SURVIVAL AND CHEMOTACTIC BEHAVIOR IN ISOLATED OSTEOCLASTS [J].

FULLER, K ;

OWENS, JM ;

JAGGER, CJ ;

WILSON, A ;

MOSS, R ;

CHAMBERS, TJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1733-1744

[9]

THE ROLE OF REACTIVE OXYGEN INTERMEDIATES IN OSTEOCLASTIC BONE-RESORPTION [J].

HALL, TJ ;

SCHAEUBLIN, M ;

JEKER, H ;

FULLER, K ;

CHAMBERS, TJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 207 (01) :280-287

[10]

EVIDENCE THAT C-SRC IS INVOLVED IN THE PROCESS OF OSTEOCLASTIC BONE-RESORPTION [J].

HALL, TJ ;

SCHAEUBLIN, M ;

MISSBACH, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 199 (03) :1237-1244

← 1 2 3 →