Degradation characteristics of PLLA-PGA bone fixation devices

被引:127
作者
Eppley, BL
Reilly, M
机构
[1] Division of Plastic Surgery, Indiana University Medical Center, Indianapolis, IN
[2] Division of Plastic Surgery, Indiana University Medical Center, Indianapolis, IN 46202-5200, 702 Barnhill Dr
关键词
poly L-lactic acid; polyglycolic acid; POLY(L-LACTIDE); FRACTURES;
D O I
10.1097/00001665-199703000-00010
中图分类号
R61 [外科手术学];
学科分类号
摘要
Parietal craniotomies of the mature rabbit skull were repositioned and fixed with resorbable plate and screws made of LactoSorb (Walter Lorenz Surgical, Jacksonville, FL) poly L-lactic acid (PLLA) and polyglycolic acid (PGA) in 20 mature rabbits. Changes in the resorbable devices as well as at the tissue-implant interface were evaluated at 2, 6, 9, and 12 months postoperatively. At 2 months, no change in the size of the implants was seen with a noninflammatory layer of surrounding fibrous tissue and intense birefringence of the screws. At 6 months, substantial loss of implant size had occurred, accompanied by fibrovascular and a macrophage cellular infiltrate. At 9 months, more than 95% of the implant was resorbed, with a small amount remaining ire the screw hale, Other than macrophages within the remaining material, very few giant cells were seen. By I year, no evidence of birefringent macromolecular polymer debris could be found. No contraindications for the clinical use of this specific PLLA-PGA copolymer could be found when implanted on craniofacial bone surfaces.
引用
收藏
页码:116 / 120
页数:5
相关论文
共 6 条
[1]   DEGRADATION OF AND TISSUE REACTION TO BIODEGRADABLE POLY(L-LACTIDE) FOR USE AS INTERNAL-FIXATION OF FRACTURES - A STUDY IN RATS [J].
BOS, RRM ;
ROZEMA, FR ;
BOERING, G ;
NIJENHUIS, AJ ;
PENNINGS, AJ ;
VERWEY, AB ;
NIEUWENHUIS, P ;
JANSEN, HWB .
BIOMATERIALS, 1991, 12 (01) :32-36
[2]   RESORBABLE POLY(L-LACTIDE) PLATES AND SCREWS FOR THE FIXATION OF ZYGOMATIC FRACTURES [J].
BOS, RRM ;
BOERING, G ;
ROZEMA, FR ;
LEENSLAG, JW .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1987, 45 (09) :751-753
[3]  
BOSTMAN OM, 1992, CLIN ORTHOP RELAT R, P263
[4]   A COMPARISON OF RESORBABLE AND METALLIC FIXATION IN HEALING OF CALVARIAL BONE-GRAFTS [J].
EPPLEY, BL ;
SADOVE, AM .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1995, 96 (02) :316-322
[5]   EXAMINATION OF EFFERENT LYMPH-NODES AFTER 2 YEARS OF TRANSCORTICAL IMPLANTATION OF POLY(L-LACTIDE) CONTAINING PLUGS - A CASE-REPORT [J].
VERHEYEN, CCPM ;
DEWIJN, JR ;
VANBLITTERSWIJK, CA ;
ROZING, PM ;
DEGROOT, K .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1993, 27 (08) :1115-1118
[6]  
Zhong S. P., 1993, Clinical Materials, V14, P145, DOI 10.1016/0267-6605(93)90037-8