Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E-2: further evidence for the importance of vagal afferents in immune-to-brain communication

被引：25

作者：

Milligan, ED ^{[1
]}

McGorry, MM ^{[1
]}

Fleshner, M ^{[1
]}

Gaykema, RPA ^{[1
]}

Goehler, LE ^{[1
]}

Watkins, LR ^{[1
]}

Maier, SF ^{[1
]}

机构：

[1] UNIV COLORADO,DEPT PSYCHOL,BOULDER,CO 80309

来源：

BRAIN RESEARCH | 1997年 / 766卷 / 1-2期

关键词：

prostaglandin E-2 (PGE(2)); hyperthermia; vagotomy; c-fos; sickness; rat; immediate-early gene;

D O I：

10.1016/S0006-8993(97)00705-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-mediated sickness responses can be blocked by subdiaphragmatic vagotomy, suggesting that vagal afferents signal peripheral inflammation or infection. This study tested whether subdiaphragmatic vagotomy disrupts sickness responses by interrupting effector pathways. If this explanation is correct, intracerebroventricular prostaglandin E-2-induced fever should be blocked by this procedure. Fever was unaffected by subdiaphragmatic vagotomy, thus these data provide support for the conclusion that vagal afferents signal the brain during immune activation. (C) 1997 Elsevier Science B.V.

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收藏

页码：240 / 243

页数：4

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