LIPOPOLYSACCHARIDE AND INTERLEUKIN-1 DEPRESS FOOD-MOTIVATED BEHAVIOR IN MICE BY A VAGAL-MEDIATED MECHANISM

被引：182

作者：

BRETDIBAT, JL ^{[1
]}

BLUTHE, RM ^{[1
]}

KENT, S ^{[1
]}

KELLEY, KW ^{[1
]}

DANTZER, R ^{[1
]}

机构：

[1] UNIV ILLINOIS, DEPT ANIM SCI, URBANA, IL 61801 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 1995年 / 9卷 / 03期

关键词：

D O I：

10.1006/brbi.1995.1023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to assess the role of vagal nerve afferents in the decrease in food-motivated behavior induced by proinflammatory cytokines, the effects of lipopolysaccharide (LPS, 400 mu g/kg ip) and recombinant human interleukin-1 beta (IL-1, 750-1500 ng/mouse ip) were tested on nose poke for food in vagotomized and sham-operated mice. Subdiaphragmatic vagotomy attenuated the decrease in response rate induced by IL-1 and LPS. These results suggest that the peripheral immune message is transmitted to the brain via a neural rather than a humoral pathway. (C) 1995 Academic Press. Inc.

引用

页码：242 / 246

页数：5

共 18 条

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