Membrane sensors for batch and flow injection potentiometric determination of ethamsylate (Cyclonamine) in pharmaceutical preparations

The lipophilic nickel(II) and iron(II) bathophenanthroline derivatives of ethamsylate are used as ion-exchangers with high selectivity characteristics for ethamsylate. Poly(vinyl chloride) membrane sensors incorporating these electroactive materials display fast linear response for 1 x 10(-1) - 1 x 10(-4) M ethamsylate under static and hydrodynamic modes of operation. In an acetate buffer of pH 4, the calibration slope is 51-53 mV/concentration decade and the lower limit of detection is 5.3 mu g/ml. Except for salicylate and nitrate, most common anions, organic sulfonates, carboxylates, phenolates and various pharmaceutical excipients and diluents do not interfere. Determination of ethamsylate in various dosage forms shows an average recovery of 98.9% of the nominal and a mean standard deviation of 0.7%.