Anticonvulsant activity of analogues of acetazolamide

被引：45

作者：

Chufán, EE

Pedregosa, JC

Baldini, ON

Bruno-Blanch, L

机构：

[1] Univ Nacl La Plata, Fac Ciencias Exactas, Div Farmacia, RA-2431900 La Plata, Argentina

[2] Univ Nacl San Luis, Fac Quim Bioquim & Farmacia, RA-5700 San Luis, Argentina

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

anticonvulsant activity; maximal electroshock test; acetazolamide; sulfonamides; carbonic anhydrase inhibition;

D O I：

10.1016/S0014-827X(99)00096-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anticonvulsant activity of 5-tertbutyloxycarbonylamido-1,3,4-thiadiazole-2-sulfonamide (B-H(2)ats) and 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats) was compared in mice, to that of acetazolamide (H(2)acm). These compounds exhibit potent anticonvulsant activity and low minimal motor impairment. (C) 1999 Elsevier Science S.A. All lights reserved.

引用

页码：838 / 841

页数：4

共 17 条

[11] METAL-COMPLEXES OF 5-TERTBUTYLOXYCARBONYLAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE (B-H(2)ATS), A CARBONIC-ANHYDRASE INHIBITOR - SYNTHESIS AND CHARACTERIZATION OF THE COPPER(II) COMPLEX - CRYSTAL-STRUCTURES OF B-H(2)ATS AND THE [CU(B-ATS)(NH3)(2)](2) DIMER COMPLEX [J].