Changes in striatal dopamine release in stress-induced conditioned suppression of motility in rats

被引：13

作者：

Katoh, A

Nabeshima, T

Kuno, A

Wada, M

Ukai, R

Kameyama, T

机构：

[1] MEIJO UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,NAGOYA,AICHI 468,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM,NAGOYA,AICHI 466,JAPAN

来源：

BEHAVIOURAL BRAIN RESEARCH | 1996年 / 77卷 / 1-2期

关键词：

conditioned fear stress; dopamine; conditioned suppression of motility; striatum; in vivo microdialysis;

D O I：

10.1016/0166-4328(95)00228-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats received a footshock for 10 min in a chamber with a metallic grid floor, and then placed into the chamber for 30 min after 6 days. The motility of the shocked rats showed a significant decrease (conditioned suppression of motility). In addition, the extracellular dopamine (DA) levels in the striatum were also reduced significantly in in vivo microdialysis study. Thus, dysfunction in the striatal DAergic neuronal systems is responsible for mental stress responses such as conditioned fear stress.

引用

页码：219 / 221

页数：3

共 8 条

[1]

FANSELOW MS, 1980, PAVLOVIAN J BIOL SCI, V15, P177

[2]

KAMEYAMA T, 1982, NEUROPHARMACOLOGY, V21, P1283, DOI 10.1016/0028-3908(82)90134-4

[3] EFFECTS OF APOMORPHINE AND METHAMPHETAMINE ON A QUICKLY-LEARNED CONDITIONED-SUPPRESSION RESPONSE IN RATS [J].