Pathogenesis of amebiasis

被引：31

作者：

Petri, WA ^{[1
]}

机构：

[1] Univ Virginia Hlth Syst, Div Infect Dis, Charlottesville, VA 22908 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2002年 / 5卷 / 04期

关键词：

D O I：

10.1016/S1369-5274(02)00335-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It is an exciting time in the study of Entamoeba histolytica. Over the past two years, the natural history and burden of disease in humans has been redefined, mucosal immune responses associated with protection identified, and the developmental regulation of encystation outlined. The number of genes sequenced has increased from a few hundred to a few thousand, and study of the genome structure is revealing unusual repetitive elements and plasticity. DNA microarrays promise the first ability to examine global patterns of mRNA abundance. The mechanism of transcriptional control via histone modifications and sequence-specific DNA-binding proteins are to be delineated. Advances in cell biology are providing new insights into invasion through the intestinal epithelium.

引用

页码：443 / 447

页数：5

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