NOTCH SIGNALING IN CHONDROGENESIS

被引：19

作者：

Karlsson, Camilla ^{[1
]}

Lindahl, Anders ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Clin Chem & Transfus Med, Sahlgrenska Univ Hosp, Gothenburg, Sweden

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 275 | 2009年 / 275卷

关键词：

Notch signaling; Chondrocytes; HES; Cartilage development; Osteoarthritis; MESENCHYMAL PROGENITOR CELLS; LOOP-HELIX FACTORS; NEURAL STEM-CELL; ARTICULAR-CARTILAGE; DNA-BINDING; NEGATIVE REGULATOR; DROSOPHILA-HAIRY; MAMMALIAN HAIRY; EXPRESSION; DIFFERENTIATION;

D O I：

10.1016/S1937-6448(09)75003-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The different stages of cartilage development are well described but no transcription factor capable of specifically inducing differentiation to articular cartilage has been identified and little is known about the molecular mechanisms regulating cartilage development. Notch signaling is an evolutionarily conserved pathway taking part in many developmental and cell type specification processes. it has been demonstrated that markers for Notch signaling are differentially expressed during cartilage development and there is evidence for their functional role during this process. Notch signaling has further been implicated in osteoarthritis and Notch1 has been suggested as a marker for chondrogenic progenitor cells. This review summarizes the current knowledge on the role of the Notch signaling pathway in cartilage development and osteoarthritis.

引用

页码：65 / 88

页数：24

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