Regulatory effects of vasoactive intestinal peptide on the migration of mature dendritic cells

被引：17

作者：

Weng, Yuesong

Sun, Juyun

Wu, Qianqian

Pan, Hanping

机构：

[1] Zhejiang Univ, Inst Immunol, Hangzhou 310058, Peoples R China

[2] Lishui Coll, Sch Med, Dept Microbiol & Immunol, Lishui 323000, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 182卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

vasoactive intestinal peptide; dendritic cells; migration; CCR1; CCR7;

D O I：

10.1016/j.jneuroim.2006.09.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The neuropeptide vasoactive intestinal peptide (VIP), released within lymphoid organs from nerve terminals and/or immune cells, plays a significant anti-inflammatory role. It was reported that VIP can induce regulatory dendritic cells (DCs) and promote Th2-type responses. However, the regulatory effect of VIP on the migration and expression of chemokine receptors by DC is mostly unknown. In the present study, we show that VIP exerts a differential effect on the expression of CCR1 and CCR7 by lipopolysaccharide (LPS)-treated mature DCs (mDCs) at both protein and mRNA levels. It up-regulates CCR1 expression but down-regulates CCR7 expression in LPS-stimulated mature DC, thereby differentially regulating the migration of mature DCs in response to CCL5 and CCL19. Our data indicate that VIP functions as a key endogenous anti-inflammatory agent by inhibiting migration of mDCs to draining lymph nodes, thus preventing the induction of an inflammatory immune response. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：48 / 54

页数：7

共 18 条

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