Recombinational repair and restart of damaged replication forks

被引：340

作者：

McGlynn, P ^{[1
]}

Lloyd, RG ^{[1
]}

机构：

[1] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrm951

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.

引用

页码：859 / 870

页数：12

共 121 条

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