Involvement of the direct striatonigral pathway in levodopa-induced sensitization in 6-hydroxydopamine-lesioned rats

被引:115
作者
Bordet, R
Ridray, S
Schwartz, JC
Sokoloff, P
机构
[1] Ctr Paul Broca, INSERM, U109, Unite Neurobiol & Pharmacol Mol, F-75014 Paris, France
[2] Univ Paris 05, Physiol Lab, F-75006 Paris, France
关键词
dopamine D-3 receptor; Parkinson's disease; preprotachykinin; prodynorphin;
D O I
10.1046/j.1460-9568.2000.00089.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Induction of dopamine D-3 receptor gene expression in 6-hydroxydopamine-lesioned rats by repeated administration of levodopa had been suggested to be responsible for behavioural sensitization developing in these animals. Using double in situ hybridization techniques, we show that D-3 receptor mRNA induction after repeated administration of levodopa took place mainly in dynorphin/substance P-expressing neurons of the direct striatonigral pathway. In agreement, induction of D-3 receptor binding sites was evidenced, using 7-[H-3]hydroxy-N,N-di-propyl-2-aminotetralin ([H-3]7-OH-DPAT), in substantia nigra pars reticulata, the projection area of the direct nigrostriatonigral pathway. Changes in D-3 receptor binding and behavioural sensitization during intermittent administration of levodopa paralleled changes in prodynorphin/preprotachykinin rather than preproenkephalin/prodynorphin and preproenkephalin/preprotachykinin mRNA ratios. Behavioural sensitization, induction of D-3 receptor binding and changes in prodynorphin/preprotachykinin ratio were all prevented together when levodopa was continuously delivered or intermittently delivered in combination with R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390), a selective D-1 receptor antagonist. Our results indicate that functional changes of the direct striatal output pathway, possibly through an interaction between D-1 and D-3 receptors at the level of terminals in the substantia nigra pars reticulata, are important for the development of behavioural sensitization.
引用
收藏
页码:2117 / 2123
页数:7
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