Finding effective cancer therapies through loss of function genetic screens

被引：19

作者：

Bernards, Rene ^{[1
,2
]}

机构：

[1] Netherlands Canc Inst, Canc Syst Biol Ctr, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Canc Genom Ctr Netherlands, NL-1066 CX Amsterdam, Netherlands

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 24卷

基金：

欧洲研究理事会;

关键词：

SYNTHETIC LETHAL INTERACTION; ACQUIRED-RESISTANCE; RNA INTERFERENCE; MEK INHIBITION; TGF-BETA; CELLS; BRAF; IDENTIFICATION; NEUROBLASTOMA; TRASTUZUMAB;

D O I：

10.1016/j.gde.2013.11.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intrinsic or acquired drug resistance often limits the success of cancer treatment. Loss of function genetic screens can help identify mechanisms of drug resistance and thereby deliver strategies to combat resistance. A further application of these genetic screens is the identification of drug targets whose inactivation is only effective in a specific context. This synthetic lethality approach enables the identification of drugs that act only in cancer cells having a cancer-specific mutation and the discovery of potent combination therapies. This review focuses on the question how functional genetic screens can help to improve the treatment of cancer.

引用

页码：23 / 29

页数：7

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