TGF-β An emerging player in drug resistance

被引：119

作者：

Brunen, Diede ^{[1
,2
]}

Willems, Stefan M. ^{[1
]}

Kellner, Udo ^{[3
]}

Midgley, Rachel ^{[4
]}

Simon, Iris ^{[5
]}

Bernards, Rene ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands

[2] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[3] Johannes Wesling Klinikum Minden, Inst Pathol, Minden, Germany

[4] Univ Oxford, Dept Oncol, Oxford, England

[5] Agendia, Amsterdam, Netherlands

来源：

CELL CYCLE | 2013年 / 12卷 / 18期

关键词：

TGF-beta; EMT; chemotherapy; drug resistance; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; EXPRESSION SIGNATURE; COLORECTAL-CANCER; COLON-CANCER; SENSITIVITY; RECEPTOR; P53; CARCINOMA; APOPTOSIS;

D O I：

10.4161/cc.26034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The transforming growth factor beta (TGF-beta) pathway acts as a double-edged sword in tumorigenesis. By constraining epithelial cell growth, TGF-beta is a potent tumor suppressor. However, TGF-beta also acts as a key player in the induction of epithelial-to-mesenchymal transition (EMT), thereby enhancing invasiveness and metastasis. Furthermore, TGF-beta signaling has recently been correlated with resistance against both targeted and conventional anticancer agents. Here, we present data demonstrating a role for TGF-beta in chemotherapy resistance in colorectal cancer (CRC). We discuss these results in the context of recent findings indicating TGF-beta signaling as an emerging player in cancer drug resistance.

引用

页码：2960 / 2968

页数：9

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