Stomatin

被引:41
作者
Stewart, GW
机构
[1] Department of Medicine, Rayne Institute, Univ. College School of Medicine, London WC1E 6JJ, University Street
基金
英国惠康基金;
关键词
red blood cell; mechanosensation; ion transport; haemolytic anaemia;
D O I
10.1016/S1357-2725(96)00072-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Stomatin is a 31-kDa integral membrane protein, named after the rare human haemolytic anaemia hereditary stomatocytosis. In some cases of this anaemia, in which the red cells leak sodium and potassium ions, this protein is absent from the membrane, immediately suggesting that it has a role in the regulation of ion transport. The protein has a single hydrophobic domain, presumed to be membrane-associated, is phosphorylated, and is widely distributed in animal tissues. Mutations of a homologue in sensory nerve cells of the nematode Caenorhabditis elegans disrupt a neuronal transduction mechanism, in which mechanosensory information is relayed to an ion channel, whose opening initiates an action potential. It could be that this protein is a molecular link in a generic stretch-sensitive system. Abnormalities of red cell ion transport are well known in human hypertension, but the molecular basis has never been elucidated: this protein and its functional associates, operating in a stretch- or pressure-sensitive complex, might be important. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:271 / 274
页数:4
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