TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture

被引：48

作者：

Porras, A

Alvarez, AM

Valladares, A

Benito, M

机构：

[1] UNIV COMPLUTENSE,FAC FARM,CTR MIXTO,CONSEJO SUPER INVEST CIENTIFICAS,INST BIOQUIM,MADRID 28040,SPAIN

[2] UNIV COMPLUTENSE,FAC FARM,CTR CITOMETRIA FLUJO & MICROSCOPIA CONFOCAL,MADRID 28040,SPAIN

来源：

FEBS LETTERS | 1997年 / 416卷 / 03期

关键词：

TNF-alpha; apoptosis; brown adipocyte;

D O I：

10.1016/S0014-5793(97)01204-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of TNF-alpha on cell death in rat fetal brown adipocytes maintained in primary culture was determined, TNF-alpha inhibited proliferation and induced apoptosis in these cells, Most of the cells undergoing apoptosis after TNF-alpha treatment did not express PCNA, suggesting an induction of apoptosis by TNF-alpha in non-proliferative cells, IGF-I but not EGF prevented TNF-alpha-induced apoptosis. (C) 1997 Federation of European Biochemical Societies.

引用

页码：324 / 328

页数：5