Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects:: results from the nationwide Diabetes Incidence Study in Sweden (DISS)

被引：209

作者：

Littorin, B.

Blom, P.

Scholin, A.

Arnqvist, H. J.

Blohme, G.

Bolinder, J.

Ekbom-Schnell, A.

Eriksson, J. W.

Gudbjornsdottir, S.

Nystrom, L.

Ostman, J.

Sundkvist, G.

机构：

[1] Sodervarn Primary Hlth Care Ctr, S-21426 Malmo, Sweden

[2] Lund Univ, Dept Clin Sci, Malmo Univ Hosp, Malmo, Sweden

[3] Electra Box Diagnost, Tyreso, Sweden

[4] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[5] Linkoping Univ, Dept Internal Med, Fac Hlth Sci, Linkoping, Sweden

[6] Soder Hosp, Dept Internal Med, Stockholm, Sweden

[7] Karolinska Univ Hosp, Dept Diabet Endocrinol & Metab, Huddinge, Sweden

[8] Univ Uppsala Hosp, Dept Internal Med, S-75185 Uppsala, Sweden

[9] Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden

[10] Sahlgrens Univ Hosp, Dept Internal Med, S-41345 Gothenburg, Sweden

来源：

DIABETOLOGIA | 2006年 / 49卷 / 12期

关键词：

25-hydroxyvitamin D; 25OHD; autoimmunity; GADA; IA-2A; ICA; islet antibodies; type; 1; diabetes; vitamin D;

D O I：

10.1007/s00125-006-0426-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes. The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15- to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age- and sex-matched control subjects (n=208). At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5 +/- 1.3 vs 96.7 +/- 2.0 nmol/l; p < 0.0001). Eight years later, plasma 25OHD had decreased in patients (81.5 +/- 2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9 +/- 1.4 vs 90.1 +/- 2.4 nmol/l; p < 0.0001) and at follow-up (77.1 +/- 2.8 nmol/l vs 87.2 +/- 4.5 nmol/l; p=0.048). 81.5 +/- 2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9 +/- 1.4 vs 90.1 +/- 2.4 nmol/l; p < 0.0001) and at follow-up (77.1 +/- 2.8 nmol/l vs 87.2 +/- 4.5 nmol/l; p=0.048). Conclusions/interpretation The plasma 25OHD level was lower at diagnosis of autoimmune type 1 diabetes than in control subjects, and may have a role in the development of type 1 diabetes. Plasma 25OHD levels were lower in men than in women with type 1 diabetes. This difference may be relevant to the high incidence of type 1 diabetes among young adult men.

引用

页码：2847 / 2852

页数：6

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