Three new pseudodistomins, piperidine alkaloids from the ascidian Pseudodistoma megalarva

被引：46

作者：

Freyer, AJ

Patil, AD

Killmer, L

Troupe, N

Mentzer, M

Carte, B

Faucette, L

Johnson, RK

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,R&D,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHYS & STRUCT CHEM,R&D,KING OF PRUSSIA,PA 19406

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 10期

关键词：

D O I：

10.1021/np9701438

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the MeOH-CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D-F (3-5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were established by interpretation of spectral data. Pseudodistomins B-F were found to be active in a cell-based assay for DNA damage induction, but the activity was due to an alternative mechanism.

引用

页码：986 / 990

页数：5

共 7 条

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