Effect of acute and chronic stress restraint on amphetamine-associated place preference:: involvement of dopamine D1 and D2 receptors

The purpose of this study was to determine the D-amphetamine (1.0, 1.5 and 2 mg/kg i.p.)-induced place preference in rats pre-exposed to acute or chronic restraint stress, using the conditioned place preference model. We also studied the involvement of opioid and dopamine mechanisms in the acute restraint stress-induced increase of D-amphetamine-induced place preference. A single restraint session (2 h) but not chronic restraint (2 h/day for 7 days) lending to adaptation to the stressor, enhanced the D-amphetamine-induced place preference. This enhancing effect was prevented by haloperidol administration (0.4 mg/kg i.p.), (+/-)-sulpiride (60 mg/kg i.p.) or R(+)-SCH-23390 hydrochloride (R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1 H-3-benzazepine hydrochloride, 30 mu g/kg i.p.) 10-20 min prior to the acute restraint session. However, naltrexone pretreatment (1 or 2 mg/kg i.p.) failed to prevent the acute restraint-induced enhancement of D-amphetamine induced place preference. These results suggest that: (1) the enhancement of D-amphetamine-induced place preference occurred after a single restraint stress but not following chronic restraint stress, (2) the stimulation of both dopamine D-1 and D-2 receptors is necessary for the development of single restraint stress-induced enhancement of D-amphetamine-induced place preference and (3) apparently, an opioid system is not involved in this acute restraint-induced effect. (C) 1999 Elsevier Science B.V. All rights reserved.