2D J-resolved spiral spectroscopic imaging at 7 T:: Application to mobile lipid mapping in a rat glioma

被引：12

作者：

Hiba, B ^{[1
]}

Serduc, R ^{[1
]}

Provent, P ^{[1
]}

Farion, R ^{[1
]}

Rémy, C ^{[1
]}

Ziegler, A ^{[1
]}

机构：

[1] Univ Grenoble 1, INSERM, Lab Mixte, U594,Ctr Hosp Univ, Grenoble, France

来源：

MAGNETIC RESONANCE IN MEDICINE | 2004年 / 52卷 / 03期

关键词：

2D J-resolved; spiral spectroscopic imaging; in vivo; rat glioma; mobile lipid; lactate; metabolite imaging;

D O I：

10.1002/mrm.20166

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Lactate (Lac) and mobile lipids (Lip), which are present in rat gliomas, are difficult to map because their H-1 resonances overlap in the 1.3 ppm region. 2D J-resolved spectroscopy enables proper separation of the two resonance lines. To obtain highspatial-resolution mapping of Lac and Lip resonances within a reasonable experiment time, we coupled 2D J-resolved spectroscopy with a fast spectroscopic imaging (SI) method, based on an out-and-in spiral k-space description. The method was applied to a rat glioma at 7 T, and Lac and Lip maps were reconstructed. The duration of SI (2D spatial, 2D spectral) was 64 min for a theoretical in-plane resolution of 1 x 1 mm, and a slice thickness of 2 mm (voxel size 8.2 mul, taking into account the point-spread function (PSF)). (C) 2004 Wiley-Liss, Inc.

引用

页码：658 / 662

页数：5

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