共 54 条
Clinical and pathological evidence for a frontal variant of Alzheimer disease
被引:285
作者:

Johnson, JK
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA

Head, E
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA

Kim, R
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA

Starr, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA

Cotman, CW
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA
机构:
[1] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA
关键词:
D O I:
10.1001/archneur.56.10.1233
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Objective: To evaluate the clinical and pathological features of a subgroup of patients with Alzheimer disease (AD) who exhibited early and disproportionately severe impairments on tests of frontal lobe functioning. We hypothesized that these patients would exhibit a greater degree of either neurofibrillary tangle (NFT) or senile plaque pathology in the frontal lobes than would patients with typical AD. Design and Outcome Measures: We examined the neuropsychological profiles and senile plaque and NFT accumulation in the frontal, entorhinal, temporal, and parietal cortices in 3 patients with AD who exhibited disproportionate frontal impairments during early stages of dementia (frontal AD) and 3 matched patients with typical AD (typical AD). Results: Compared with the typical AD group, the frontal AD group performed significantly worse on 2 tests of frontal lobe functioning and on the Wechsler Adult Intelligence Scale-Revised Block Design test. No significant group differences were found on other tests. Analysis of brain tissue samples demonstrated that, despite comparable entorhinal, temporal, and parietal NFT loads, the frontal AD group showed a significantly higher NFT load in the frontal cortex than the typical AD group. Senile plaque pathology in the frontal and entorhinal cortices did not differentiate the 2 groups. Conclusions: We identified a subgroup of patients with pathologically confirmed AD who presented in the early stages of dementia with disproportionate impairments on tests of frontal lobe functioning and had a greater-than-expected degree of NFT pathology in the frontal lobes, suggesting the existence of a frontal variant of AD that has distinctive clinical and pathological features.
引用
收藏
页码:1233 / 1239
页数:7
相关论文
共 54 条
[1]
NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE
[J].
ARRIAGADA, PV
;
GROWDON, JH
;
HEDLEYWHYTE, ET
;
HYMAN, BT
.
NEUROLOGY,
1992, 42 (03)
:631-639

ARRIAGADA, PV
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02114

GROWDON, JH
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02114

HEDLEYWHYTE, ET
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02114

HYMAN, BT
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02114
[2]
Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22
[J].
Baker, M
;
Kwok, JBJ
;
Kucera, S
;
Crook, R
;
Farrer, M
;
Houlden, H
;
Isaacs, A
;
Lincoln, S
;
Onstead, L
;
Hardy, J
;
Wittenberg, L
;
Dodd, P
;
Webb, S
;
Hayward, N
;
Tannenberg, T
;
Andreadis, A
;
Hallupp, M
;
Schofield, P
;
Dark, F
;
Hutton, M
.
ANNALS OF NEUROLOGY,
1997, 42 (05)
:794-798

Baker, M
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Kwok, JBJ
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Kucera, S
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Crook, R
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Farrer, M
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Houlden, H
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Isaacs, A
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Lincoln, S
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Onstead, L
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Hardy, J
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Wittenberg, L
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Dodd, P
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Webb, S
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Hayward, N
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Tannenberg, T
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Andreadis, A
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Hallupp, M
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Schofield, P
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Dark, F
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224

Hutton, M
论文数: 0 引用数: 0
h-index: 0
机构: MAYO CLIN JACKSONVILLE,JACKSONVILLE,FL 32224
[3]
Clinical characteristics of a chromosome 17-linked rapidly progressive familial frontotemporal dementia
[J].
Basun, H
;
Almkvist, O
;
Axelman, K
;
Brun, A
;
Campbell, TA
;
Collinge, J
;
Forsell, C
;
Froelich, S
;
Wahlund, LO
;
Wetterberg, L
;
Lannfelt, L
.
ARCHIVES OF NEUROLOGY,
1997, 54 (05)
:539-544

Basun, H
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Almkvist, O
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Axelman, K
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Brun, A
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Campbell, TA
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Collinge, J
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Forsell, C
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Froelich, S
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Wahlund, LO
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Wetterberg, L
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN

Lannfelt, L
论文数: 0 引用数: 0
h-index: 0
机构: KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN
[4]
NEUROPSYCHOLOGICAL FUNCTION IN ALZHEIMERS-DISEASE - PATTERN OF IMPAIRMENT AND RATES OF PROGRESSION
[J].
BECKER, JT
;
HUFF, FJ
;
NEBES, RD
;
HOLLAND, A
;
BOLLER, F
.
ARCHIVES OF NEUROLOGY,
1988, 45 (03)
:263-268

BECKER, JT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, SCH MED, DEPT PSYCHIAT, PITTSBURGH, PA 15213 USA

HUFF, FJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, SCH MED, DEPT PSYCHIAT, PITTSBURGH, PA 15213 USA

NEBES, RD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, SCH MED, DEPT PSYCHIAT, PITTSBURGH, PA 15213 USA

HOLLAND, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, SCH MED, DEPT PSYCHIAT, PITTSBURGH, PA 15213 USA

BOLLER, F
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, SCH MED, DEPT PSYCHIAT, PITTSBURGH, PA 15213 USA
[5]
ALZHEIMERS-DISEASE IN A PATIENT WITH POSTERIOR CORTICAL ATROPHY
[J].
BERTHIER, ML
;
LEIGUARDA, R
;
STARKSTEIN, SE
;
SEVLEVER, G
;
TARATUTO, AL
.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,
1991, 54 (12)
:1110-1111

BERTHIER, ML
论文数: 0 引用数: 0
h-index: 0
机构: INST NEUROL RES DR RAUL CARREA,BUENOS AIRES,ARGENTINA

LEIGUARDA, R
论文数: 0 引用数: 0
h-index: 0
机构: INST NEUROL RES DR RAUL CARREA,BUENOS AIRES,ARGENTINA

STARKSTEIN, SE
论文数: 0 引用数: 0
h-index: 0
机构: INST NEUROL RES DR RAUL CARREA,BUENOS AIRES,ARGENTINA

SEVLEVER, G
论文数: 0 引用数: 0
h-index: 0
机构: INST NEUROL RES DR RAUL CARREA,BUENOS AIRES,ARGENTINA

TARATUTO, AL
论文数: 0 引用数: 0
h-index: 0
机构: INST NEUROL RES DR RAUL CARREA,BUENOS AIRES,ARGENTINA
[6]
Executive dysfunction in early Alzheimer's disease
[J].
Binetti, G
;
Magni, E
;
Padovani, A
;
Cappa, SF
;
Bianchetti, A
;
Trabucchi, M
.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,
1996, 60 (01)
:91-93

Binetti, G
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

论文数: 引用数:
h-index:
机构:

Padovani, A
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

Cappa, SF
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

Bianchetti, A
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

Trabucchi, M
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY
[7]
Focal cortical atrophy syndromes
[J].
Black, SE
.
BRAIN AND COGNITION,
1996, 31 (02)
:188-229

Black, SE
论文数: 0 引用数: 0
h-index: 0
机构: SUNNYBROOK HLTH SCI CTR, RES PROGRAM AGING, N YORK, ON M4N 3M5, CANADA
[8]
STAGING OF ALZHEIMERS-DISEASE-RELATED NEUROFIBRILLARY CHANGES
[J].
BRAAK, H
;
BRAAK, E
.
NEUROBIOLOGY OF AGING,
1995, 16 (03)
:271-278

BRAAK, H
论文数: 0 引用数: 0
h-index: 0
机构: Department of Anatomy, J. W. Goethe University, D-60590 Frankfurt

BRAAK, E
论文数: 0 引用数: 0
h-index: 0
机构: Department of Anatomy, J. W. Goethe University, D-60590 Frankfurt
[9]
NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES
[J].
BRAAK, H
;
BRAAK, E
.
ACTA NEUROPATHOLOGICA,
1991, 82 (04)
:239-259

BRAAK, H
论文数: 0 引用数: 0
h-index: 0
机构:
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY

BRAAK, E
论文数: 0 引用数: 0
h-index: 0
机构:
ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY ZENTRUM MORPHOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
[10]
Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17
[J].
Clark, LN
;
Poorkaj, P
;
Wszolek, Z
;
Geschwind, DH
;
Nasreddine, ZS
;
Miller, B
;
Li, D
;
Payami, H
;
Awert, F
;
Markopoulou, K
;
Andreadis, A
;
D'Souza, I
;
Lee, VMY
;
Reed, L
;
Trojanowski, JQ
;
Zhukareva, V
;
Bird, T
;
Schellenberg, G
;
Wilhelmsen, KC
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (22)
:13103-13107

Clark, LN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Poorkaj, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Wszolek, Z
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Geschwind, DH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Nasreddine, ZS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Miller, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Li, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Payami, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Awert, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Markopoulou, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Andreadis, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

D'Souza, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Lee, VMY
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Reed, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Trojanowski, JQ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Zhukareva, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Bird, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Schellenberg, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

Wilhelmsen, KC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA