The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

被引：182

作者：

Zhao, Jean J.

Cheng, Hailing

Jia, Shidong

Wang, Li

Gjoerup, Ole V.

Mikami, Aki

Roberts, Thomas M.

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 44期

关键词：

adipocyte differentiation; cancer therapy; conditional knockout; PIK3CA;

D O I：

10.1073/pnas.0607899103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks). Among this class of enzymes, only p110 alpha, encoded by the PIK3CA gene, has been found to be mutant in human cancers. To determine the specific functions of p110 alpha, we generated mice carrying a conditionally targeted allele of the PIK3CA gene. Here, we report that PIK3CA-knockout mouse embryonic fibroblasts are deficient in cellular signaling in response to various growth factors, unable to differentiate into adipocytes, and resistant to oncogenic transformation induced by a variety of oncogenic receptor tyrosine kinases, indicating a fundamental role for p110 alpha in these biological processes.

引用

页码：16296 / 16300

页数：5

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