Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from southwestern Uganda with uncomplicated falciparum malaria

被引：19

作者：

Legros, D

Johnson, K

Houpikian, P

Makanga, M

Kabakyenga, JK

Talisuna, AO

Taylor, WRJ

机构：

[1] Epictr, Kampala, Uganda

[2] French Embassy, Kampala, Uganda

[3] Mharara Univ, Mharara, Uganda

[4] Minist Hlth, Entebbe, Uganda

[5] UCL Royal Free & Univ Coll Med Sch, Ctr Infect Dis, Windeyer Inst, London W1P 6DB, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2002年 / 96卷 / 02期

关键词：

malaria; Plasmodium falciparum; chemotherapy; chloroquine; sulfadoxine-pyrimethamine; children; efficacy; Uganda;

D O I：

10.1016/S0035-9203(02)90304-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We conducted a 14-day study (during March-May 1998) to assess the efficacy of chloroquine and sulfadoxine-pyrimethamine (SP) for treating uncomplicated Plasmodium falciparum malaria in Uganda. Overall treatment failure rates were 43 (81.1%) of 53 chloroquine recipients and 16 (25.0%) of 64 SP patients. Strategies to improve the life-span of standard and affordable antimalarial drugs are needed.

引用

页码：199 / 201

页数：3

共 13 条

[1]

[Anonymous], 1996, WHOMAL961077

[2] Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in Uganda:: Correlation with polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes [J].