Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes

被引:93
作者
Liu, Yanfang
Michael, M. Dodson
Kash, Shera
Bensch, William R.
Monia, Brett P.
Murray, Susan F.
Otto, Keith A.
Syed, Samreen K.
Bhanot, Sanjay
Sloop, Kyle W.
Sullivan, John M.
Reifel-Miller, Anne [1 ]
机构
[1] Eli Lilly & Co, Lilly Res Labs, Type 2 Diabet Drug Hunting Team, Indianapolis, IN 46285 USA
[2] Lilly Res Labs, Atherosclerosis Drug Hunting Team, Indianapolis, IN 46285 USA
[3] Lilly Res Labs, Discovery Pathol, Indianapolis, IN 46285 USA
[4] Deltagen Inc, San Carlos, CA 94070 USA
[5] ISIS Pharmaceut, Carlsbad, CA 92008 USA
关键词
D O I
10.1210/en.2006-0708
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adiponectin/adiponectin receptors (AdipoR) are involved in energy homeostasis and inflammatory pathways. To investigate the role of AdipoR2 in metabolic control, we studied the lipid and glucose metabolic phenotypes in AdipoR2-deficient mice. AdipoR2 deletion diminished high-fat diet-induced dyslipidemia and insulin resistance yet deteriorated glucose homeostasis as high-fat feeding continued, which resulted from the failure of pancreatic beta-cells to adequately compensate for the moderate insulin resistance. A defect in the AdipoR2 gene may represent a mechanism underlying the etiology of certain subgroups of type 2 diabetic patients who eventually develop overt diabetes, whereas other obese patients do not.
引用
收藏
页码:683 / 692
页数:10
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