Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion

被引：71

作者：

Behrens, Adam M. ^{[1
]}

Lee, Nora G. ^{[2
]}

Casey, Brendan J. ^{[3
]}

Srinivasan, Priya ^{[2
]}

Sikorski, Michael J. ^{[1
]}

Daristotle, John L. ^{[1
]}

Sandler, Anthony D. ^{[2
]}

Kofinas, Peter ^{[1
]}

机构：

[1] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

[2] Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC 20010 USA

[3] US FDA, Div Biol Chem & Mat Sci, Off Sci & Engn Labs, Off Med Prod & Tobacco,Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 48期

基金：

美国国家卫生研究院;

关键词：

TISSUE ADHESIVES; POLYETHYLENE-GLYCOL; NANOFIBERS; ANASTOMOSIS; COMPONENTS; SCAFFOLDS; HEMOSTATS; NANOSHEET; SURFACES; HYDROGEL;

D O I：

10.1002/adma.201503691

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.

引用

页码：8056 / 8061

页数：6

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