Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives

被引:24
作者
Takayama, S [1 ]
Moree, WJ [1 ]
Wong, CH [1 ]
机构
[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0040-4039(96)01378-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Racemic amines and amino alcohols were enzymatically resolved by enantioselective acylation using cyanomethyl pent-4-enoate or by enantioselective enzymatic hydrolysis of the dipent-4-enoyl derivatives of amino alcohols to afford chiral pent-4-enamides which can be deacylated chemically to their chiral amines under mild conditions. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:6287 / 6290
页数:4
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