Stem cells and cancer: an intimate relationship

被引:99
作者
Burkert, J.
Wright, N. A.
Alison, M. R.
机构
[1] Canc Res UK, Histopathol Unit, London WC2A 3PX, England
[2] Barts & London Queen Marys Sch Med & Dent, ICMS, London E1 2AT, England
关键词
carcinogenesis; stem cell; cancer stem cell; clonogenicity; metaplasia; dysplasia; Wnt signalling; hedgehog signalling; Bmi1; notch; jagged; haematopoietic stem cell (HSC); side population (SP); self-renewal; myofibroblast;
D O I
10.1002/path.2016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumour-wide 'omics' approaches have long held sway as the approach to identifying useful therapeutic targets. This view is changing with the realization that many, if not all, cancers contain a minority population of self-renewing stem cells, the cancer stem cells, which are entirely responsible for sustaining the tumour as well as giving rise to proliferating but progressively differentiating cells that are responsible for much of the cellular heterogeneity that is so familiar to histopathologists. Moreover, although many tumours probably have their origins in normal stem cells, persuasive evidence from the haematopoietic system suggests that genetic alterations in more committed progenitor cells can reactivate the self-renewal machinery, resulting in a further source of cancer stem cells. Thus, the bulk of the tumour is not the problem, and so the identification of cancer stem cells and the factors that regulate their behaviour are likely to have an enormous bearing on the way that we treat neoplastic disease in the future. Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
引用
收藏
页码:287 / 297
页数:11
相关论文
共 124 条
  • [31] Stem cells in normal breast development and breast cancer
    Dontu, G
    Al-Hajj, M
    Abdallah, WA
    Clarke, MF
    Wicha, MS
    [J]. CELL PROLIFERATION, 2003, 36 : 59 - 72
  • [32] Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    Dontu, G
    Jackson, KW
    McNicholas, E
    Kawamura, MJ
    Abdallah, WM
    Wicha, MS
    [J]. BREAST CANCER RESEARCH, 2004, 6 (06): : R605 - R615
  • [33] Transplanted bone marrow cells preferentially home to the vessels of in situ generated murine tumors rather than of normal organs
    Dwenger, A
    Rosenthal, F
    Machein, M
    Waller, C
    Spyridonidis, A
    [J]. STEM CELLS, 2004, 22 (01) : 86 - 92
  • [34] Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis
    Epperly, MW
    Guo, HL
    Gretton, JE
    Greenberger, JS
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2003, 29 (02) : 213 - 224
  • [35] A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis
    Forbes, SJ
    Russo, FP
    Rey, V
    Burra, P
    Rugge, M
    Wright, NA
    Alison, MR
    [J]. GASTROENTEROLOGY, 2004, 126 (04) : 955 - 963
  • [36] Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    Galli, R
    Binda, E
    Orfanelli, U
    Cipelletti, B
    Gritti, A
    De Vitis, S
    Fiocco, R
    Foroni, C
    Dimeco, F
    Vescovi, A
    [J]. CANCER RESEARCH, 2004, 64 (19) : 7011 - 7021
  • [37] Molecular phenotype of airway side population cells
    Giangreco, A
    Shen, HM
    Reynolds, SD
    Stripp, BR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 286 (04) : L624 - L630
  • [38] Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction
    Giangreco, A
    Reynolds, SD
    Stripp, BR
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (01) : 173 - 182
  • [39] Role of polycomb group proteins in stem cell self-renewal and cancer
    Gil, J
    Bernard, D
    Peters, G
    [J]. DNA AND CELL BIOLOGY, 2005, 24 (02) : 117 - 125
  • [40] Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    Goodell, MA
    Brose, K
    Paradis, G
    Conner, AS
    Mulligan, RC
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) : 1797 - 1806