Strategies to optimise propofol-opioid anaesthesia

被引：43

作者：

Lichtenbelt, BJ ^{[1
]}

Mertens, M ^{[1
]}

Vuyk, J ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Anaesthesiol, NL-2300 RC Leiden, Netherlands

来源：

CLINICAL PHARMACOKINETICS | 2004年 / 43卷 / 09期

关键词：

D O I：

10.2165/00003088-200443090-00002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Propofol-opioid combinations are widely used in today's anaesthetic practice. Over the past 20-30 years the pharmacology of these agents has been described in increasingly greater detail. Together with novel intravenous administration devices and improved anaesthetic depth monitoring, this has created a basis for the optimisation of the administration of propofol-opioid anaesthesia. This article describes the current strategies regarding the application of this type of anaesthesia, focusing on three strategic tools: (i) application of pharmacokinetic-pharmacodynamic knowledge of propofol and the opioids, with particular attention to pharmacodynamic interactions between them; (ii) the use of state-of-the-art administration techniques; and (iii) the application of bispectral index monitoring. Together, these techniques have improved the level of control, the flexibility and the safety of anaesthetic practice.

引用

页码：577 / 593

页数：17

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