Transperineal photodynamic ablation of the canine prostate

被引:49
作者
Selman, SH [1 ]
Keck, RW [1 ]
Hampton, JA [1 ]
机构
[1] MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699
关键词
photochemotherapy; prostatic neoplasms;
D O I
10.1016/S0022-5347(01)66012-9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Experiments were undertaken to determine the effects of transperineal interstitial photodynamic therapy on the canine prostate. Materials and Methods: Mongrel dogs were injected intravenously with the photosensitizer tin (II) ethyl etiopurpurin dichloride. Twenty-four hours later, 2 optical fibers were implanted in 1 hemisphere of the prostate, which was then treated with red light (660 nm.). Results: Acutely, the treated areas showed extensive hemorrhagic necrosis. At 3 and 6 weeks, the treated lobes were largely replaced by fibrous connective tissue. Conclusion: Transperineal photodynamic therapy of the canine prostate is feasible. Further preclinical investigation is warranted to determine the applicability of this approach to the treatment of localized prostate cancer.
引用
收藏
页码:258 / 260
页数:3
相关论文
共 8 条
[1]   PHOTODYNAMIC THERAPY OF PROSTATE-CANCER - AN INVITRO STUDY [J].
CAMPS, JL ;
POWERS, SK ;
BECKMAN, WC ;
BROWN, JT ;
WEISSMAN, RM .
JOURNAL OF UROLOGY, 1985, 134 (06) :1222-1226
[2]  
DOUGHERTY TJ, 1978, CANCER RES, V38, P2628
[3]  
Gad S.C., 1986, Statistics and Experimental Design for Toxicologist
[4]   INTERSTITIAL APPLICATIONS OF LASER IRRADIATION IN HEMATOPORPHYRIN DERIVATIVE-PHOTOSENSITIZED DUNNING R3327 PROSTATE CANCERS [J].
MCPHEE, MS ;
THORNDYKE, CW ;
THOMAS, G ;
TULIP, J ;
CHAPMAN, D ;
LAKEY, WH .
LASERS IN SURGERY AND MEDICINE, 1984, 4 (01) :93-98
[5]   PHOTODYNAMIC THERAPY FOR LOCALIZED PROSTATIC-CANCER - LIGHT PENETRATION IN THE HUMAN PROSTATE-GLAND [J].
PANTELIDES, ML ;
WHITEHURST, C ;
MOORE, JV ;
KING, TA ;
BLACKLOCK, NJ .
JOURNAL OF UROLOGY, 1990, 143 (02) :398-401
[6]   THE EFFECT OF TRANSURETHRAL LIGHT ON THE CANINE PROSTATE AFTER SENSITIZATION WITH THE PHOTOSENSITIZER TIN(II) ETIOPURPURIN DICHLORIDE - A PILOT-STUDY [J].
SELMAN, SH ;
KECK, RW .
JOURNAL OF UROLOGY, 1994, 152 (06) :2129-2132
[7]  
WEIBEL ER, 1987, STEREOLOGICAL METHOD
[8]   PHOTODYNAMIC THERAPY OF LOCALIZED PROSTATIC-CANCER [J].
WINDAHL, T ;
ANDERSSON, SO ;
LOFGREN, L .
LANCET, 1990, 336 (8723) :1139-1139