THE EFFECT OF TRANSURETHRAL LIGHT ON THE CANINE PROSTATE AFTER SENSITIZATION WITH THE PHOTOSENSITIZER TIN(II) ETIOPURPURIN DICHLORIDE - A PILOT-STUDY

被引:31
作者
SELMAN, SH
KECK, RW
机构
[1] Department of Urology, Medical College of Ohio, Toledo, OH 43699-0008
关键词
PROSTATE; PROSTATIC HYPERTROPHY; PHOTOCHEMOTHERAPY;
D O I
10.1016/S0022-5347(17)32337-6
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
A pilot study was undertaken to determine the effect of transurethral light on photosensitized periurethral prostatic tissue in the dog. Initial studies demonstrated that a sufficient level of the photosensitizer tin (II) etiopurpurin dichloride, SnET2, was present in the canine prostate 24 hours after intravenous administration to create a photodynamic effect. Gross and histologic examination of SnET2 photosensitized prostates treated transurethrally with 285 joules per cm. of red light (660 nm.) showed hemorrhagic necrosis as much as 1 cm. from the urethral wall. Three weeks after treatment, circumferential glandular atrophy was evident within the treatment area. The urethral mucosa, which was histologically absent at the 48-hour interval, regenerated by 3 weeks. Transurethral photodynamic treatment of the prostate is feasible, and its use for the treatment of benign prostatic hyperplasia warrants further investigation.
引用
收藏
页码:2129 / 2132
页数:4
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