QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents

被引：44

作者：

Agrawal, VK

Bano, S

Supuran, C

Khadikar, PV

机构：

[1] Laxmi Fumigat & Pest Control Pvt Ltd, Div Res, Indore 452007, India

[2] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Sesto Fiorentino, Italy

[3] APS Univ, QSAR & Comp Chem Labs, Rewa 486003, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 07期

关键词：

QSAR; carbonic anhydrase inhibitors; valence connectivity; regression analysis; aromatic; hetrocyclic sulfonamides;

D O I：

10.1016/j.ejmech.2004.03.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quantitative structure-activity-relation ship (QSAR) study on aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl carbonic anhydrase (CA) inhibitors has been carried out topologically using first-order valence connectivity index ((1)chi(v)). Excellent results are obtained against all the three isozymes; CA I, II and IV of the zinc enzyme CA by using indicator parameters along with (1)chi(v). (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：593 / 600

页数：8

共 19 条

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