The role of phosphoinositide 3-kinase in insulin signalling

被引：60

作者：

Shepherd, PR ^{[1
]}

Nave, BT ^{[1
]}

ORahilly, S ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT CLIN BIOCHEM,CAMBRIDGE CB2 2QR,ENGLAND

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 1996年 / 17卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1677/jme.0.0170175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：175 / 184

页数：10

共 92 条

[71] INSULIN ACTIVATES GLYCOGEN-SYNTHASE BY A NOVEL PI-3 KINASE/P70(S6K) DEPENDENT PATHWAY IN 3T3-L1 ADIPOCYTES [J].

SHEPHERD, PR ;

NAVE, BT ;

SIDDLE, K .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1995, 23 (02) :S202-S202

[72] THE SH2 SH3 DOMAIN-CONTAINING PROTEIN GRB2 INTERACTS WITH TYROSINE-PHOSPHORYLATED IRS1 AND SHC - IMPLICATIONS FOR INSULIN CONTROL OF RAS SIGNALING [J].

SKOLNIK, EY ;

LEE, CH ;

BATZER, A ;

VICENTINI, LM ;

ZHOU, M ;

DALY, R ;

MYERS, MJ ;

BACKER, JM ;

ULLRICH, A ;

WHITE, MF ;

SCHLESSINGER, J .

EMBO JOURNAL, 1993, 12 (05) :1929-1936

[73] CHARACTERIZATION OF A PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOINOSITIDE 3-KINASE FROM MAMMALIAN-CELLS [J].

STEPHENS, L ;

COOKE, FT ;

WALTERS, R ;

JACKSON, T ;

VOLINIA, S ;

GOUT, I ;

WATERFIELD, MD ;

HAWKINS, PT .

CURRENT BIOLOGY, 1994, 4 (03) :203-214

[74] A NOVEL PHOSPHOINOSITIDE-3 KINASE-ACTIVITY IN MYELOID-DERIVED CELLS IS ACTIVATED BY G-PROTEIN BETA-GAMMA-SUBUNITS [J].

STEPHENS, L ;

SMRCKA, A ;

COOKE, FT ;

JACKSON, TR ;

STERNWEIS, PC ;

HAWKINS, PT .

CELL, 1994, 77 (01) :83-93

[75] AGONIST-STIMULATED SYNTHESIS OF PHOSPHATIDYLINOSITOL(3,4,5)-TRISPHOSPHATE - A NEW INTRACELLULAR SIGNALING SYSTEM [J].

STEPHENS, LR ;

JACKSON, TR ;

HAWKINS, PT .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1179 (01) :27-75

[76] CLONING AND CHARACTERIZATION OF A G-PROTEIN-ACTIVATED HUMAN PHOSPHOINOSITIDE-3 KINASE [J].

STOYANOV, B ;

VOLINIA, S ;

HANCK, T ;

RUBIO, I ;

LOUBTCHENKOV, M ;

MALEK, D ;

STOYANOVA, S ;

VANHAESEBROECK, B ;

DHAND, R ;

NURNBERG, B ;

GIERSCHIK, P ;

SEEDORF, K ;

HSUAN, JJ ;

WATERFIELD, MD ;

WETZKER, R .

SCIENCE, 1995, 269 (5224) :690-693

[77]

TANTI JF, 1996, EXPT CLIN ENDOCRIN S, V101, P25

[78] MULTIPLE DEFECTS IN MUSCLE GLYCOGEN-SYNTHASE ACTIVITY CONTRIBUTE TO REDUCED GLYCOGEN-SYNTHESIS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].

THORBURN, AW ;

GUMBINER, B ;

BULACAN, F ;

BRECHTEL, G ;

HENRY, RR .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) :489-495

[79]

TOKER A, 1994, J BIOL CHEM, V269, P32358

[80] MULTIPLE ROLES OF PHOSPHATIDYLINOSITOL 3-KINASE IN REGULATION OF GLUCOSE-TRANSPORT, AMINO-ACID-TRANSPORT, AND GLUCOSE TRANSPORTERS IN L6 SKELETAL-MUSCLE CELLS [J].

TSAKIRIDIS, T ;

MCDOWELL, HE ;

WALKER, T ;

DOWNES, CP ;

HUNDAL, HS ;

VRANIC, M ;

KLIP, A .

ENDOCRINOLOGY, 1995, 136 (10) :4315-4322

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