Synthesis of alkaloid 223A and a structural revision

被引：58

作者：

Toyooka, N ^{[1
]}

Fukutome, A ^{[1
]}

Nemoto, H ^{[1
]}

Daly, JW ^{[1
]}

Spande, TF ^{[1
]}

Garraffo, HM ^{[1
]}

Kaneko, T ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Sugitani, Toyama 9300194, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 10期

关键词：

D O I：

10.1021/ol025775m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Synthesis of alkaloid 223A has been achieved by sequential use of our original conjugate addition reaction to enaminoesters as the key step. The proposed structure for natural 223A (A, absolute configuration unknown) was revised to B, and the relative stereostructure was determined to be 5R*,6R*,8R*,9S* by the present synthesis.

引用

页码：1715 / 1717

页数：3

共 26 条

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