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The promise and pitfalls of monoclonal antibody therapeutics

被引：24
作者：
Berkower, I
机构：
[1] Laboratory of Immunoregulation, Div. of Allergenic Prod. and P., Ctr. for Biologics, Food and Admin., Bethesda
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1996年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0958-1669(96)80073-5
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent experience has helped io clarify the best ways to use monoclonal antibodies to solve clinical problems. For example, imaging based on tumor antigens, rather than tumor size, will permit early detection of cancer and accurate staging. Blocking receptor-ligand interactions may permit therapeutic intervention in cell growth or function but activity may depend on the choice of an antiligand or antireceptor strategy. Humanized antibodies will achieve greater intensity and duration of therapy, while allowing repeat administration in chronic diseases. (C) Current Biology Ltd ISSN 0958-1669..
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页码：622 / 628
页数：7
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