Wnt Signaling Mediates Experience-Related Regulation of Synapse Numbers and Mossy Fiber Connectivities in the Adult Hippocampus

被引：159

作者：

Gogolla, Nadine ^{[1
]}

Galimberti, Ivan ^{[1
]}

Deguchi, Yuichi ^{[1
]}

Caroni, Pico ^{[1
]}

机构：

[1] Friedrich Miescher Inst, CH-4058 Basel, Switzerland

来源：

NEURON | 2009年 / 62卷 / 04期

关键词：

PATTERN SEPARATION; DENTATE GYRUS; RAT HIPPOCAMPUS; PLASTICITY; CA3; TRANSMISSION; TERMINALS; STRESS; CELLS; RELEASE;

D O I：

10.1016/j.neuron.2009.04.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated how experience regulates the structure of a defined neuronal circuit in adult mice. Enriched environment (EE) produced a robust and reversible increase in hippocampal stratum lucidum synapse numbers, mossy fiber terminal (LMT) numbers, and spine plus synapse densities at LMTs, whereas a distinct mechanism depending on Rab3a promoted LMT volume growth. In parallel, EE increased postsynaptic CA3 pyramidal neuron Wnt7a/b levels. Inhibiting Writ signaling through locally applied sFRP-1 suppressed the effects of EE on synapse numbers and further reduced synapse numbers in control mice. Wnt7 applied to CA3 mimicked the effects of EE on synapse and LMT numbers. CA3 Wnt7a/b levels were enhanced by excitatory activity and reduced by sFRP-1. Synapse numbers and Wnt7a/b levels peaked in mice aged 6-12 months; a decline in aged mice was reversed by EE. Therefore, behavioral experience specifically regulates adult global stratum lucidum synapse numbers and hippocampal network structure through Writ signaling.

引用

页码：510 / 525

页数：16

共 56 条

[51] Rapid reversal of stress induced loss of synapses in CA3 of rat hippocampus following water maze training [J].