Evolutionary ideas about genetically manipulated mosquitoes and malaria control

被引：39

作者：

Boëte, C ^{[1
]}

Koella, JC ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, Lab Parasitol Evolut, UMR 7103, F-75252 Paris 05, France

来源：

TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 01期

关键词：

D O I：

10.1016/S1471-4922(02)00003-X

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The release of mosquitoes that are genetically manipulated to destroy the malaria parasite Plasmodium falciparum is being considered as a possible method for malaria control. Hopes for this have been raised by the identification of genes involved in the mosquito's immune response and by advances in the tools required to transform mosquitoes. But, will such genes be able to spread in natural populations? What will their impact be on epidemiology of the disease? This article attempts to give some answers to these questions by reviewing some theoretical and empirical considerations underlying the evolutionary epidemiology of genetic manipulation and refractoriness.

引用

页码：32 / 38

页数：7

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