Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise

被引：99

作者：

Duman, Catharine H. ^{[1
]}

Schlesinger, Lee ^{[1
]}

Terwilliger, Rosemarie ^{[1
]}

Russell, David S. ^{[1
]}

Newton, Samuel S. ^{[1
]}

Duman, Ronald S. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, Abraham Ribicoff Res Facil,Div Mol Psychiat, New Haven, CT 06508 USA

[2] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06508 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 198卷 / 02期

关键词：

Antidepressant; IGF-I; Behavior; Mouse; Exercise; Forced-swim test; Novelty-induced hypophagia; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; CHRONIC MILD STRESS; HIPPOCAMPAL NEUROGENESIS; ANIMAL-MODELS; IGF-I; NEURODEGENERATIVE DISEASES; NEUROTROPHIC FACTORS; SYNAPTIC PLASTICITY; INDUCED INCREASES;

D O I：

10.1016/j.bbr.2008.11.016

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：366 / 371

页数：6

共 58 条

[31] Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis [J].