Machine learning in bioinformatics

被引：498

作者：

Larranaga, Pedro

Calvo, Borja

Santana, Roberto

Bielza, Concha

Galdiano, Josu

Inza, Inaki

Lozano, Jose A.

Armananzas, Ruben

Santafe, Guzman

Perez, Aritz

Robles, Victor

机构：

[1] Univ Basque Country, Dept Comp Sci & Artificial Intelligence, Intelligent Syst Grp, San Sebastian 20018, Spain

[2] Madrid Tech Univ, Sch Comp Sci, Madrid, Spain

[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[4] Univ Politecn Madrid, Dept Comp Syst Architecture & Technol, E-28040 Madrid, Spain

来源：

BRIEFINGS IN BIOINFORMATICS | 2006年 / 7卷 / 01期

关键词：

machine learning; bioinformatics; supervised classification; clustering; probabilistic graphical models; optimisation; heuristic; genomics; proteomics; microarray; system biology; evolution; text mining;

D O I：

10.1093/bib/bbk007

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reviews machine learning methods for bioinformatics. It presents modelling methods, such as supervised classification, clustering and probabilistic graphical models for knowledge discovery, as well as deterministic and stochastic heuristics for optimization. Applications in genomics, proteomics, systems biology, evolution and text mining are also shown.

引用

页码：86 / 112

页数：27

共 273 条

[21] Prediction of the phenotypic effects of non-synonymous single nucleotide polymorphisms using structural and evolutionary information [J].

Bao, L ;

Cui, Y .

BIOINFORMATICS, 2005, 21 (10) :2185-2190

[22] LVB: parsimony and simulated annealing in the search for phylogenetic trees [J].

Barker, D .

BIOINFORMATICS, 2004, 20 (02) :274-275

[23] Supervised machine learning techniques for the classification of metabolic disorders in newborns [J].

Baumgartner, C ;

Böhm, C ;

Baumgartner, D ;

Marini, G ;

Weinberger, K ;

Olgemöller, B ;

Liebl, B ;

Roscher, AA .

BIOINFORMATICS, 2004, 20 (17) :2985-2996

[24]

Ben-Bassat M., 1982, Handbook of statistics, V2, P773, DOI DOI 10.1016/S0169-7161(82)02038-0

[25] Tissue classification with gene expression profiles [J].

Ben-Dor, A ;

Bruhn, L ;

Friedman, N ;

Nachman, I ;

Schummer, M ;

Yakhini, Z .

JOURNAL OF COMPUTATIONAL BIOLOGY, 2000, 7 (3-4) :559-583

[26] Parallel Monte Carlo methods for physical mapping of chromosomes [J].

Bhandarkar, SM ;

Huang, JL ;

Arnold, J .

CSB2002: IEEE COMPUTER SOCIETY BIOINFORMATICS CONFERENCE, 2002, :64-75

[27]

BLANCO R, 2001, P WORKSH BAY MOD MED, P29

[28]

Blazewicz J, 2005, LECT NOTES COMPUT SC, V3449, P22

[29] Application of tabu search strategy for finding low energy structure of protein [J].

Blazewicz, J ;

Lukasiak, P ;

Milostan, M .

ARTIFICIAL INTELLIGENCE IN MEDICINE, 2005, 35 (1-2) :135-145

[30] RNA tertiary structure determination: NOE pathways construction by tabu search [J].

Blazewicz, J ;

Szachniuk, M ;

Wojtowicz, A .

BIOINFORMATICS, 2005, 21 (10) :2356-2361

← 1 2 3 4 5 6 7 8 9 10 →