Cyclooxygenase-2 and colorectal cancer chemoprevention:: The β-catenin connection

被引：74

作者：

Castellone, Maria Domenica

Teramoto, Hidemi

Gutkind, J. Silvio

机构：

[1] NIDCR, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA

[2] Kojin Hosp, Nagoya, Aichi, Japan

来源：

CANCER RESEARCH | 2006年 / 66卷 / 23期

关键词：

D O I：

10.1158/0008-5472.CAN-06-2233

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer poses a major clinical challenge in the developed world where this disease is common. Recent findings suggest that the prostaglandin E-2, the proinflammatory product of elevated cyclooxygenase-2 activity in colon cancer, stimulates cancer cell growth through a G protein-dependent signaling pathway coupling the prostaglandin EP2 receptor to beta-catenin control. These findings provide new insights into the molecular framework needed to evaluate chemopreventive strategies for colorectal cancer.

引用

收藏

页码：11085 / 11088

页数：4

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