The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?

被引：172

作者：

Bien, Justyna ^{[2
]}

Palagani, Vindhya ^{[1
]}

Bozko, Przemyslaw ^{[1
]}

机构：

[1] Univ Tubingen, Dept Internal Med 1, Fac Med, D-72076 Tubingen, Germany

[2] Polish Acad Sci, Witold Stefanski Inst Parasitol, Warsaw, Poland

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2013年 / 6卷 / 01期

关键词：

Clostridium difficile; inflammatory bowel disease; microbial dysbiosis; 16S RIBOSOMAL-RNA; NF-KAPPA-B; ACID-SUPPRESSIVE AGENTS; TOXIN-B; SIGNALING PATHWAYS; FECAL MICROBIOTA; EGF RECEPTOR; ACTIVATION; DIVERSITY; DIARRHEA;

D O I：

10.1177/1756283X12454590

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological conditions like Clostridium difficile infection or inflammatory bowel disease (IBD). In this review, we focus on the role of microbial dysbiosis in initiation of C. difficile infection and IBD, and we also touch upon the role of specific pathogens, particularly C. difficile, as causative agents of IBD. We also discuss the molecular mechanisms activated by C. difficile that contribute to the development and exacerbation of gastrointestinal disorders.

引用

页码：53 / 68

页数：16

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