Viruses and Hodgkin's lymphoma

被引:85
作者
Jarrett, RF [1 ]
机构
[1] Univ Glasgow, Fac Med Vet, Inst Comparat Med, LRF Virus Ctr, Glasgow G61 1QH, Lanark, Scotland
关键词
epidemiology; Epstein-Barr virus; herpesvirus; Hodgkin's lymphoma; infectious mononucleosis; latent membrane protein;
D O I
10.1093/annonc/13.S1.23
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hodgkin's lymphoma (HL) is unusual among human malignancies in that the epidemiology suggests an infectious aetiology. The Epstein-Barr vir-us (EBV) is associated with a proportion of cases and this association is believed to be causal. In these cases the Hodgkin and Reed-Sternberg (HRS) cells express the EBV-encoded proteins LMP1 and LMP2, which can mimic CD40 and the B cell receptor, respectively, and therefore may play a critical role in facilitating the survival of HRS cells. EBV-associated and non-EBV-associated HL cases have different epidemiological features and recent data Suggest that delayed exposure to EBV is a risk factor for the development of EBV-associated HL in young adults. We suggest that HL can be divided into four entities on the basis of EBV status and age at presentation, with three groups of EBV-associated cases and a single group of EBV-negative cases. The aetiology of the latter cases is obscure although involvement of an infectious agent(s) is suspected.
引用
收藏
页码:23 / 29
页数:7
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