Sexually dimorphic expression of a teleost homologue of Mullerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus

被引：105

作者：

Yoshinaga, N

Shiraishi, E

Yamamoto, T

Iguchi, T

Abe, S

Kitano, T

机构：

[1] Kumamoto Univ, Grad Sch Sci & Technol, Dept Mat & Life Sci, Kumamoto 8608555, Japan

[2] Hiroshima Univ, Grad Sch Sci, Dept Math & Life Sci, Higashihiroshima 7398526, Japan

[3] Okazaki Natl Res Inst, Ctr Integrat Biosci, Okazaki, Aichi 4448585, Japan

[4] Kumamoto Univ, Fac Sci, Kumamoto 8608555, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 322卷 / 02期

关键词：

Mullerian inhibiting substance; anti-Mullerian hormone; aromatase; sex differentiation; teleost; Japanese flounder;

D O I：

10.1016/j.bbrc.2004.07.162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mullerian inhibiting substance (MIS), also known as anti-Mullerian hormone, is a glycoprotein belonging to transforming growth factor beta superfamily. In mammals, MIS is responsible for regression of Mullerian ducts, anlagen of the female reproductive ducts, in the male fetus. However, the role of MIS in gonadal sex differentiation of teleost fishes, which do not have the Mullerian ducts, has yet to be clarified. To address the role of MIS on gonadal sex differentiation in fishes, we isolated a MIS cDNA from the Japanese flounder testis and examined the expression pattern of MIS mRNA in gonads of both sexes during sex differentiation period. In this study, we present the first demonstration of sexually dimorphic expression of MIS mRNA during sex differentiation in teleost fishes, similarly to amniote vertebrates which possess the Mullerian ducts. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：508 / 513

页数：6

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[12] STEROIDOGENIC FACTOR-I, AN ORPHAN NUCLEAR RECEPTOR, REGULATES THE EXPRESSION OF THE RAT AROMATASE GENE IN GONADAL TISSUES [J].