Synthesis of sialic acid-containing saccharides

被引：40

作者：

Adak, Avijit K. ^{[1
]}

Yu, Ching-Ching ^{[1
]}

Liang, Chien-Fu ^{[1
]}

Lin, Chun-Cheng ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2013年 / 17卷 / 06期

关键词：

SITE-SPECIFIC IMMOBILIZATION; STEREOSELECTIVE-SYNTHESIS; CHEMOENZYMATIC SYNTHESIS; NEISSERIA-MENINGITIDIS; MAGNETIC NANOPARTICLES; EFFICIENT SYNTHESIS; DONORS; SIALYLATION; PHOSPHITE; ALPHA-2,3-SIALYLTRANSFERASE;

D O I：

10.1016/j.cbpa.2013.10.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Sialic acids are a diverse family of negatively charged monosaccharides with a shared nine-carbon carboxylated backbone, and they often serve as the terminal positions of cell surface glycoproteins and glycolipids. Sialic acids play essential roles in mediating or modulating numerous pathological, biological, and immunological recognition events. Advances in synthesis have provided chemically well-defined and structurally homogeneous sialic acid-containing carbohydrates that are crucial for studying glycobiology. This review highlights recent innovations in the chemical and chemoenzymatic synthesis of difficult alpha-sialosides, with a particular focus on methods developed for alpha-selective sialylation in the synthesis of O-linked and S-linked oligosialic acids.

引用

页码：1030 / 1038

页数：9

共 63 条

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