Thiooligosaccharide conjugate vaccines evoke antibodies specific for native antigens

被引：81

作者：

Bundle, DR ^{[1
]}

Rich, JR

Jacques, S

Yu, HN

Nitz, M

Ling, CC

机构：

[1] Univ Alberta, Dept Chem, Alberta Ingenuity Ctr Carbohydrate Sci, Edmonton, AB T6G 2G2, Canada

[2] Serono Res Inst, Rockland, MA 02370 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 47期

关键词：

antibodies; carbohydrates; conjugate vaccines; glycoconjugates; glycosides;

D O I：

10.1002/anie.200502179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

When S is SO much better: Conjugate vaccines that contain S-glycosides induce carbohydrate-specific antibodies that cross react with the corresponding O-glycosides and vice versa. Four distinct systems have been examined, in each of which the antigen-specific response to S-glycosides is either comparable or superior to the response to O-glycosides. (Figure Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7725 / 7729

页数：5

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