Crosstalk Between Agrin and Wnt Signaling Pathways in Development of Vertebrate Neuromuscular Junction

被引：86

作者：

Barik, Arnab ^{[1
]}

Zhang, Bin ^{[1
]}

Sohal, Gurkirpal S. ^{[2
]}

Xiong, Wen-Cheng ^{[1
,3
,4
]}

Mei, Lin ^{[1
,3
,4
]}

机构：

[1] Georgia Regents Univ, Dept Neurosci & Regenerat Med, Med Coll Georgia, Augusta, GA 30912 USA

[2] Georgia Regents Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA

[3] Charlie Norwood VA Med Ctr, Augusta, GA 30904 USA

[4] Georgia Regents Univ, Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2014年 / 74卷 / 08期

关键词：

NMJ; WNT; LRP4; musk; aneural clusters; ACETYLCHOLINE-RECEPTOR; BETA-CATENIN; SYNAPTIC DIFFERENTIATION; MOTOR-NEURONS; MUSCLE; MUSK; PROTEIN; RAPSYN; APC; AGGREGATION;

D O I：

10.1002/dneu.22190

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Neuromuscular junction (NMJ) is a cholinergic synapse where motor neurons elicit muscle contraction. Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation. This paper reviews recent evidence for Wnts and Wnt signaling molecules in NMJ formation including a possible retrograde mechanism by muscle beta-catenin. We also present data that Wnt3a, 7a, 8a and 10b could inhibit agrin-mediated AChR clustering. Together with the stimulating effect of Wnt9a, 9b, 10b, 11 and 16 on AChR clustering in the absence of agrin, these results suggest diverse roles for Wnt ligands in NMJ development. (C) 2014 Wiley Periodicals, Inc.

引用

页码：828 / 838

页数：11

共 79 条

[1]

Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold [J].

Apel, ED ;

Glass, DJ ;

Moscoso, LM ;

Yancopoulos, GD ;

Sanes, JR .

NEURON, 1997, 18 (04) :623-635

[2]

A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration [J].

Banerjee, Santanu ;

Gordon, Laura ;

Donn, Thomas M. ;

Berti, Caterina ;

Moens, Cecilia B. ;

Burden, Steven J. ;

Granato, Michael .

DEVELOPMENT, 2011, 138 (15) :3287-3296

[3]

Barik A., 2012, Protein kinase technologies, P203

[4]

Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization [J].

Barth, Angela I. M. ;

Caro-Gonzalez, Hector Y. ;

Nelson, W. James .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2008, 19 (03) :245-251

[5]

Agrin is a differentiation-inducing ''stop signal'' for motoneurons in vitro [J].

Campagna, JA ;

Ruegg, MA ;

Bixby, JL .

NEURON, 1995, 15 (06) :1365-1374

[6]

Casein kinase 2-dependent serine phosphory ation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction [J].

Cheusova, Tatiana ;

Khan, Muhammad Amir ;

Schubert, Steffen Wolfgang ;

Gavin, Anne-Claude ;

Buchou, Thierry ;

Jacob, Germaine ;

Sticht, Heinrich ;

Allende, Jorge ;

Boldyreff, Brigitte ;

Brenner, Hans Rudolf ;

Hashemolhosseini, Said .

GENES & DEVELOPMENT, 2006, 20 (13) :1800-1816

[7]

From neuronal activity to the actin cytoskeleton:: A role for CaMKKs and βPIX in spine morphogenesis [J].

Ciani, Lorenza ;

Salinas, Patricia C. .

NEURON, 2008, 57 (01) :3-4

[8]

Wnt/β-Catenin Signaling and Disease [J].

Clevers, Hans ;

Nusse, Roel .

CELL, 2012, 149 (06) :1192-1205

[9]

Wnt signaling and the activation of myogenesis in mammals [J].

Cossu, G ;

Borello, U .

EMBO JOURNAL, 1999, 18 (24) :6867-6872

[10]

The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo [J].

DeChiara, TM ;

Bowen, DC ;

Valenzuela, DM ;

Simmons, MV ;

Poueymirou, WT ;

Thomas, S ;

Kinetz, E ;

Compton, DL ;

Rojas, E ;

Park, JS ;

Smith, C ;

DiStefano, PS ;

Glass, DJ ;

Burden, SJ ;

Yancopoulos, GD .

CELL, 1996, 85 (04) :501-512

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